Lethal toxin inhibitor DN1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

致死毒素抑制剂 DN1 是一种小分子，可降低炭疽致死毒素 (LT) 的细胞毒性，是 LT 诱导的细胞焦亡的抑制剂。

Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively; protected cells irrespectively of LT concentration and reduced the pathogenicity of an additional bacterial exotoxin and several viruses, does not prevent LT internalization and catalytic activity or caspase-1 activation, also reduced the susceptibility of Drosophila melanogaster to toxin-associated bacterial infections.

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GPCR/G Protein

Antibacterial

Antibacterial

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325990-63-4

257.268

C14H12FN3O

>98% (HPLC)

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CC(=NNC(=O)C1=CC=C(C=C1)F)C2=CC=CC=N2

4-fluoro- N'-[1-(2-pyridinyl)ethylidene]benzohydrazide

(-20℃)

With Ice Pack

≥ 2 years