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Lethal toxin inhibitor DN1
CAS No. 325990-63-4
Lethal toxin inhibitor DN1 ( —— )
产品货号. M14058 CAS No. 325990-63-4
Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Lethal toxin inhibitor DN1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis.
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产品描述Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively; protected cells irrespectively of LT concentration and reduced the pathogenicity of an additional bacterial exotoxin and several viruses, does not prevent LT internalization and catalytic activity or caspase-1 activation, also reduced the susceptibility of Drosophila melanogaster to toxin-associated bacterial infections.
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同义词——
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通路GPCR/G Protein
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靶点Antibacterial
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受体Antibacterial
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研究领域——
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适应症——
化学信息
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CAS Number325990-63-4
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分子量257.27
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分子式C14H12FN3O
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(=NNC(=O)C1=CC=C(C=C1)F)C2=CC=CC=N2
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化学全称4-fluoro- N'-[1-(2-pyridinyl)ethylidene]benzohydrazide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Hartmann S, et al. ACS Infect Dis. 2018 Nov 5. doi: 10.1021/acsinfecdis.8b00231.
产品手册
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